MolNFT v1 · #47649 · protein
Crystal structure of acid phosphatase 1 (ACP1) from mus musculus
2P4U: “Crystal structure of acid phosphatase 1 (ACP1) from mus musculus”. X-ray diffraction, 1 ligand (PO4), 4 pockets (best druggability 0.64). MolNFT v1 #47649 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2P4U
- Type
- protein
- Length
- 612 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acid phosphatase 1
- EC
- 3.1.3.2
- UniProt
- Q561M1
- Ligands
- PO4
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Acid phosphatase 1 (EC 3.1.3.2) | protein | 153 | 46% helix, 15% strand | Q561M1 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 395 | 0.64 | 0.79 | 37 | empty |
| 2 | 492 | 0.63 | 0.76 | 63 | empty |
| 3 | 315 | 0.59 | 0.77 | 34 | empty |
| 4 | 54 | 0.35 | 0.79 | 12 | PO4 |
Interfaces
4 interfaces between chains.
- A–C · 547 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 214 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 203 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 87 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2P4U · Crystal structure of acid phosphatase 1 (Acp1) from Mus musculus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q561M1
- Elsewhere: RCSB PDB 2P4U · PDBe 2P4U · UniProt Q561M1
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