MolNFT v1 · #47278 · protein

Crystal structure of CD5_DIII

2OTT · T-cell surface glycoprotein CD5: “Crystal structure of CD5_DIII”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #47278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2OTT
Type: protein
Length: 186 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-cell surface glycoprotein CD5
UniProt: P06127
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 14% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	T-cell surface glycoprotein CD5	protein	94	14% helix, 37% strand	P06127
Y	T-cell surface glycoprotein CD5	protein	92	14% helix, 38% strand	P06127

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.54	0.78	31	empty

Interfaces

1 interface between chains.

X–Y · 359 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

2OTT · Crystal structure of CD5_DIII · the same entry in another collection · chain X against X, TM-score 1.00
P06127 · AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD5 (P06127) · a predicted model of the same protein · chain X against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06127
Elsewhere: RCSB PDB 2OTT · PDBe 2OTT · UniProt P06127

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