MolNFT v1 · #47275 · protein
Crystal structure of immunoglobulin-like transcript 1 (ILT1/LIR7/LILRA2)
2OTP · Leukocyte immunoglobulin-like receptor subfamily a member 2: “Crystal structure of immunoglobulin-like transcript 1 (ILT1/LIR7/LILRA2)”. X-ray diffraction, 4 pockets (best druggability 0.80). MolNFT v1 #47275 on GenesisL1: 3D…
- PDB
- 2OTP
- Type
- protein
- Length
- 387 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte immunoglobulin-like receptor subfamily a member 2
- UniProt
- Q8N149
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukocyte immunoglobulin-like receptor subfamily a member 2 | protein | 193 | 0% helix, 34% strand | Q8N149 |
| B | Leukocyte immunoglobulin-like receptor subfamily a member 2 | protein | 194 | 2% helix, 34% strand | Q8N149 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 440 | 0.80 | 0.88 | 66 | empty |
| 2 | 479 | 0.69 | 0.79 | 60 | empty |
| 3 | 284 | 0.67 | 0.82 | 41 | empty |
| 4 | 56 | 0.36 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 5079 Ų buried · 75 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2OTP · Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2) · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N149 · AlphaFold monomer V2.0 prediction for leukocyte immunoglobulin-like receptor subfamily a… · a predicted model of the same protein · chain B against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N149
- Elsewhere: RCSB PDB 2OTP · PDBe 2OTP · UniProt Q8N149
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