MolNFT v1 · #47274 · protein
N-terminal fragment of streptococcus pyogenes M1 protein
2OTO · M protein: “N-terminal fragment of streptococcus pyogenes M1 protein”. X-ray diffraction, 3 pockets (best druggability 0.81). MolNFT v1 #47274 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2OTO
- Type
- protein
- Length
- 548 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- M protein
- UniProt
- Q48WD8
- Pockets
- 3 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 97% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | M protein | protein | 137 | 97% helix, 0% strand | Q48WD8 |
| B, C | M protein | protein | 138 | 96% helix, 0% strand | Q48WD8 |
| D | M protein | protein | 135 | 96% helix, 0% strand | Q48WD8 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1139 | 0.81 | 0.82 | 83 | empty |
| 2 | 71 | 0.37 | 0.78 | 17 | empty |
| 3 | 53 | 0.29 | 0.75 | 11 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2338 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 2198 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 1653 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1500 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 492 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 2OTO · N-terminal fragment of Streptococcus pyogenes M1 protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q48WD8
- Elsewhere: RCSB PDB 2OTO · PDBe 2OTO · UniProt Q48WD8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.