MolNFT v1 · #47247 · protein

Crystal structure of znua from E. COLI

2OSV · High-affinity zinc uptake system protein znua: “Crystal structure of znua from E. COLI”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.63). MolNFT v1 #47247 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2OSV
Type: protein
Length: 525 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: High-affinity zinc uptake system protein znua
UniProt: P39172
Ligands: ZN
Pockets: 4 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	High-affinity zinc uptake system protein znua	protein	262	51% helix, 12% strand	P39172
B	High-affinity zinc uptake system protein znua	protein	263	51% helix, 12% strand	P39172

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	573	0.63	0.75	59	empty
2	56	0.34	0.77	17	empty
3	75	0.32	0.75	19	empty
4	63	0.29	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 423 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2OSV · Crystal Structure of ZnuA from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
P39172 · AlphaFold monomer V2.0 prediction for high-affinity zinc uptake system protein znua… · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P39172
Elsewhere: RCSB PDB 2OSV · PDBe 2OSV · UniProt P39172

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