MolNFT v1 · #47231 · protein
Crystal structure of a thermostable mutant of bacillus subtilis adenylate kinase (Q16L/Q199R/)
2OSB: “Crystal structure of a thermostable mutant of bacillus subtilis adenylate kinase (Q16L/Q199R/)”. X-ray diffraction, 3 ligands (AP5, ZN, MG), 5 pockets (best druggability 0.83). MolNFT v1 #47231 on GenesisL1: 3D structure, binding…
- PDB
- 2OSB
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate kinase
- EC
- 2.7.4.3
- UniProt
- P16304
- Ligands
- AP5, ZN, MG
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Adenylate kinase (EC 2.7.4.3) | protein | 216 | 50% helix, 16% strand | P16304 |
Ligands and binding sites
- AP5 · Bis(adenosine)-5'-pentaphosphate · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 709 | 0.83 | 0.87 | 85 | MG, AP5 |
| 2 | 506 | 0.81 | 0.88 | 60 | MG, AP5 |
| 3 | 99 | 0.47 | 0.80 | 14 | empty |
| 4 | 148 | 0.43 | 0.76 | 31 | empty |
| 5 | 64 | 0.33 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 662 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2OSB · Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase… · the same entry in another collection · chain A against A, TM-score 1.00
- P16304 · AlphaFold monomer V2.0 prediction for adenylate kinase (P16304) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16304
- Elsewhere: RCSB PDB 2OSB · PDBe 2OSB · UniProt P16304
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