MolNFT v1 · #47158 · protein
Crystal structure of DESC1, a new member of the type II transmembrane serine proteinases family
2OQ5 · Transmembrane protease, serine 11E: “Crystal structure of DESC1, a new member of the type II transmembrane serine proteinases family”. X-ray diffraction, 1 ligand (BEN), 1 pocket (best druggability 0.47). MolNFT v1 #47158 on…
- PDB
- 2OQ5
- Type
- protein
- Length
- 232 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transmembrane protease, serine 11E
- EC
- 3.4.21.-
- UniProt
- Q9UL52
- Ligands
- BEN
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transmembrane protease, serine 11E (EC 3.4.21.-) | protein | 232 | 9% helix, 38% strand | Q9UL52 |
Ligands and binding sites
- BEN · Benzamidine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.47 | 0.76 | 32 | BEN |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2OQ5 · Crystal structure of DESC1, a new member of the type II transmembrane serine proteinases… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UL52 · AlphaFold monomer V2.0 prediction for transmembrane protease serine 11E (Q9UL52) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UL52
- Elsewhere: RCSB PDB 2OQ5 · PDBe 2OQ5 · UniProt Q9UL52
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