MolNFT v1 · #47108 · protein
Crystal structure of the human receptor phosphatase ptprt
2OOQ · Receptor-type tyrosine-protein phosphatase T: “Crystal structure of the human receptor phosphatase ptprt”. X-ray diffraction, 1 ligand (NA), 4 pockets (best druggability 0.59). MolNFT v1 #47108 on GenesisL1: 3D structure, binding…
- PDB
- 2OOQ
- Type
- protein
- Length
- 559 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase T
- EC
- 3.1.3.48
- UniProt
- O14522
- Ligands
- NA
- Pockets
- 4 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase T (EC 3.1.3.48) | protein | 278 | 37% helix, 21% strand | O14522 |
| B | Receptor-type tyrosine-protein phosphatase T (EC 3.1.3.48) | protein | 281 | 38% helix, 22% strand | O14522 |
Ligands and binding sites
- NA · Sodium ion · metal · chains B
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.59 | 0.75 | 39 | empty |
| 2 | 114 | 0.42 | 0.77 | 22 | EDO |
| 3 | 98 | 0.40 | 0.77 | 20 | NA |
| 4 | 66 | 0.35 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 352 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2OOQ · Crystal Structure of the Human Receptor Phosphatase PTPRT · the same entry in another collection · chain A against A, TM-score 1.00
- O14522 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase T… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14522
- Elsewhere: RCSB PDB 2OOQ · PDBe 2OOQ · UniProt O14522
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