MolNFT v1 · #47040 · protein
Bence jones kwr protein- immunoglobulin light chain dimer, P4(3)2(1)2 crystal form
2OMN · Bence jones kwr protein - immunoglobulin light chain: “Bence jones kwr protein- immunoglobulin light chain dimer, P4(3)2(1)2 crystal form”. X-ray diffraction, 2 ligands (IPH, SO4), 5 pockets (best druggability 0.57). MolNFT v1…
- PDB
- 2OMN
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bence jones kwr protein - immunoglobulin light chain
- Ligands
- IPH, SO4
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bence jones kwr protein - immunoglobulin light chain | protein | 217 | 7% helix, 48% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.57 | 0.79 | 33 | empty |
| 2 | 209 | 0.57 | 0.80 | 43 | empty |
| 3 | 208 | 0.56 | 0.78 | 23 | SO4 |
| 4 | 263 | 0.51 | 0.75 | 36 | empty |
| 5 | 117 | 0.34 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1711 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 2 modified (disulfide, cyclization).
Compared structures
- 2OMN · Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P4(3)2(1)2 Crystal Form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2OMN · PDBe 2OMN
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