MolNFT v1 · #46999 · protein
Bence jones kwr protein- immunoglobulin light chain dimer, P3(2)21 crystal form
2OLD · Bence jones kwr protein - immunoglobulin light chain: “Bence jones kwr protein- immunoglobulin light chain dimer, P3(2)21 crystal form”. X-ray diffraction, 2 ligands (IPH, PO4), 6 pockets (best druggability 0.68). MolNFT v1 #46999…
- PDB
- 2OLD
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bence jones kwr protein - immunoglobulin light chain
- Ligands
- IPH, PO4
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bence jones kwr protein - immunoglobulin light chain | protein | 217 | 6% helix, 48% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.68 | 0.95 | 10 | IPH |
| 2 | 454 | 0.65 | 0.78 | 67 | empty |
| 3 | 233 | 0.59 | 0.79 | 22 | PO4 |
| 4 | 254 | 0.49 | 0.74 | 45 | PO4 |
| 5 | 84 | 0.36 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1681 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 2 modified (disulfide, cyclization).
Compared structures
- 2OLD · Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(2)21 Crystal Form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2OLD · PDBe 2OLD
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