MolNFT v1 · #46913 · protein
Crystal structure of the N-terminal domain of the human proto-oncogene NUP214/CAN
2OIT · Nucleoporin 214KDA: “Crystal structure of the N-terminal domain of the human proto-oncogene NUP214/CAN”. X-ray diffraction, 7 pockets (best druggability 0.79). MolNFT v1 #46913 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2OIT
- Type
- protein
- Length
- 434 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin 214KDA
- UniProt
- Q86XD3
- Pockets
- 7 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin 214KDA | protein | 434 | 5% helix, 44% strand | Q86XD3 |
Ligands and binding sites
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 811 | 0.79 | 0.82 | 51 | empty |
| 2 | 154 | 0.48 | 0.77 | 24 | empty |
| 3 | 103 | 0.40 | 0.77 | 22 | empty |
| 4 | 73 | 0.39 | 0.78 | 20 | empty |
| 5 | 72 | 0.37 | 0.77 | 16 | empty |
Compared structures
- 2OIT · Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86XD3
- Elsewhere: RCSB PDB 2OIT · PDBe 2OIT · UniProt Q86XD3
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