MolNFT v1 · #46755 · protein

Crystal structure of mitochondrial thioredoxin 3 from saccharomyces cerevisiae (oxidized form)

2OE3 · Thioredoxin-3: “Crystal structure of mitochondrial thioredoxin 3 from saccharomyces cerevisiae (oxidized form)”. X-ray diffraction, 2 pockets (best druggability 0.34). MolNFT v1 #46755 on GenesisL1: 3D structure, binding sites and…

PDB: 2OE3
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thioredoxin-3
UniProt: P25372
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thioredoxin-3	protein	106	41% helix, 26% strand	P25372
B	Thioredoxin-3	protein	104	39% helix, 29% strand	P25372

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	83	0.34	0.74	14	empty
2	63	0.32	0.75	12	empty

Interfaces

1 interface between chains.

A–B · 456 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2OE3 · Crystal Structure of Mitochondrial Thioredoxin 3 from Saccharomyces cerevisiae (oxidized… · the same entry in another collection · chain A against A, TM-score 1.00
P25372 · AlphaFold monomer V2.0 prediction for thioredoxin-3, mitochondrial (P25372) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25372
Elsewhere: RCSB PDB 2OE3 · PDBe 2OE3 · UniProt P25372

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