MolNFT v1 · #46690 · protein

Crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 18

2OC3 · Tyrosine-protein phosphatase non-receptor type 18: “Crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 18”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #46690 on…

PDB: 2OC3
Type: protein
Length: 279 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 18
EC: 3.1.3.48
UniProt: Q99952
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48)	protein	279	37% helix, 24% strand	Q99952

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.46	0.77	24	empty
2	67	0.36	0.78	19	empty

Compared structures

2OC3 · Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase… · the same entry in another collection · chain A against A, TM-score 1.00
Q99952 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 18… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99952
Elsewhere: RCSB PDB 2OC3 · PDBe 2OC3 · UniProt Q99952

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