MolNFT v1 · #46627 · protein
Crystal structure of ORF52 from murid herpesvirus (muhv-4) (murine gammaherpesvirus 68) at 2.1 a resolution. northeast structural genomics consortium target MHR28B.
2OA5 · Hypothetical protein BQLF2: “Crystal structure of ORF52 from murid herpesvirus (muhv-4) (murine gammaherpesvirus 68) at 2.1 a resolution.…”. X-ray diffraction, 2 pockets (best druggability 0.53). MolNFT v1 #46627 on GenesisL1: 3D…
- PDB
- 2OA5
- Type
- protein
- Length
- 189 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein BQLF2
- UniProt
- P88989
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein BQLF2 | protein | 92 | 68% helix, 10% strand | P88989 |
| B | Hypothetical protein BQLF2 | protein | 97 | 68% helix, 9% strand | P88989 |
Ligands and binding sites
- PE5 · 3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.53 | 0.87 | 14 | empty |
| 2 | 64 | 0.29 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2204 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 2OA5 · Crystal structure of ORF52 from Murid herpesvirus (MUHV-4) (Murine gammaherpesvirus 68)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P88989
- Elsewhere: RCSB PDB 2OA5 · PDBe 2OA5 · UniProt P88989
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