MolNFT v1 · #46590 · protein
Crystal structure of the "-35 element" promoter recognition domain of mycobacterium tuberculosis sigc
2O8X · Probable RNA polymerase sigma-C factor: “Crystal structure of the "-35 element" promoter recognition domain of mycobacterium tuberculosis sigc”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.77). MolNFT v1 #46590…
- PDB
- 2O8X
- Type
- protein
- Length
- 183 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable RNA polymerase sigma-C factor
- UniProt
- P66809
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Probable RNA polymerase sigma-C factor | protein | 61 | 72% helix, 0% strand | P66809 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 9 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.77 | 0.84 | 31 | empty |
| 2 | 119 | 0.49 | 0.79 | 16 | SO4 |
| 3 | 135 | 0.48 | 0.78 | 15 | SO4 |
| 4 | 106 | 0.44 | 0.78 | 14 | SO4 |
Interfaces
3 interfaces between chains.
- A–C · 559 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 533 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 496 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2O8X · Crystal structure of the "-35 element" promoter recognition domain of Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P66809
- Elsewhere: RCSB PDB 2O8X · PDBe 2O8X · UniProt P66809
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