MolNFT v1 · #46561 · protein

Crystal structure of K206E mutant of N-lobe human transferrin

2O84 · Serotransferrin: “Crystal structure of K206E mutant of N-lobe human transferrin”. X-ray diffraction, 3 ligands (FE, K, CO3), 2 pockets (best druggability 0.71). MolNFT v1 #46561 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2O84
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serotransferrin
UniProt: P02787
Ligands: FE, K, CO3
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Serotransferrin	protein	329	34% helix, 20% strand	P02787

Ligands and binding sites

FE · Fe (III) ion · metal · chains X
K · Potassium ion · metal · chains X
CO3 · Carbonate ion · ion · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	189	0.71	0.88	42	empty
2	73	0.34	0.76	15	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

2O84 · Crystal structure of K206E mutant of N-lobe human transferrin · the same entry in another collection · chain X against X, TM-score 1.00
P02787 · AlphaFold monomer V2.0 prediction for serotransferrin (P02787) · a predicted model of the same protein · chain X against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02787
Elsewhere: RCSB PDB 2O84 · PDBe 2O84 · UniProt P02787

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