MolNFT v1 · #46539 · protein
Crystal structure of trimeric coiled coil GCN4 leucine zipper
2O7H · General control protein GCN4: “Crystal structure of trimeric coiled coil GCN4 leucine zipper”. X-ray diffraction, 2 pockets (best druggability 0.60). MolNFT v1 #46539 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2O7H
- Type
- protein
- Length
- 190 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General control protein GCN4
- UniProt
- P03069
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 5 distinct chains · 92% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General control protein GCN4 | protein | 33 | 91% helix, 0% strand | P03069 |
| B | General control protein GCN4 | protein | 30 | 93% helix, 0% strand | P03069 |
| C | General control protein GCN4 | protein | 33 | 91% helix, 0% strand | P03069 |
| D | General control protein GCN4 | protein | 32 | 94% helix, 0% strand | P03069 |
| E, F | General control protein GCN4 | protein | 31 | 94% helix, 0% strand | P03069 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 355 | 0.60 | 0.77 | 47 | empty |
| 2 | 125 | 0.40 | 0.74 | 14 | empty |
Interfaces
9 interfaces between chains.
- A–C · 824 Ų buried · 6 hydrogen bonds · protein-protein
- D–F · 763 Ų buried · 8 hydrogen bonds · protein-protein
- D–E · 748 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 735 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 726 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2O7H · Crystal structure of trimeric coiled coil GCN4 leucine zipper · the same entry in another collection · chain F against F, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain C against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03069
- Elsewhere: RCSB PDB 2O7H · PDBe 2O7H · UniProt P03069
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