MolNFT v1 · #46524 · protein

Tyrosine ammonia-lyase from rhodobacter sphaeroides

2O6Y · Putative histidine ammonia-lyase: “Tyrosine ammonia-lyase from rhodobacter sphaeroides”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #46524 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2O6Y
Type: protein
Length: 4,114 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative histidine ammonia-lyase
EC: 4.3.1.-
UniProt: Q3IWB0
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Putative histidine ammonia-lyase (EC 4.3.1.-)	protein	515	56% helix, 7% strand	Q3IWB0
C, D, E, F, G, H	Putative histidine ammonia-lyase (EC 4.3.1.-)	protein	514	56% helix, 7% strand	Q3IWB0

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	135	0.81	0.98	38	empty
2	288	0.80	0.92	53	empty
3	122	0.80	0.98	31	empty
4	148	0.80	0.97	33	empty
5	126	0.80	0.97	33	empty

Interfaces

18 interfaces between chains.

A–D · 4667 Å² buried · 69 hydrogen bonds · protein-protein
F–G · 4664 Å² buried · 70 hydrogen bonds · protein-protein
E–H · 4663 Å² buried · 71 hydrogen bonds · protein-protein
B–C · 4654 Å² buried · 68 hydrogen bonds · protein-protein
A–B · 3165 Å² buried · 50 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (nonstandard).

Compared structures

2O6Y · Tyrosine ammonia-lyase from Rhodobacter sphaeroides · the same entry in another collection · chain B against B, TM-score 1.00
Q3IWB0 · AlphaFold monomer V2.0 prediction for tyrosine ammonia-lyase (Q3IWB0) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3IWB0
Elsewhere: RCSB PDB 2O6Y · PDBe 2O6Y · UniProt Q3IWB0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.