MolNFT v1 · #46523 · protein
Crystal structure of procathepsin L1 from fasciola hepatica
2O6X · Secreted cathepsin L 1: “Crystal structure of procathepsin L1 from fasciola hepatica”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #46523 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2O6X
- Type
- protein
- Length
- 306 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Secreted cathepsin L 1
- EC
- 3.4.22.15
- UniProt
- Q7JNQ9
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Secreted cathepsin L 1 (EC 3.4.22.15) | protein | 306 | 37% helix, 21% strand | Q7JNQ9 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.39 | 0.79 | 15 | empty |
| 2 | 85 | 0.35 | 0.75 | 16 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2O6X · Crystal Structure of ProCathepsin L1 from Fasciola hepatica · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7JNQ9
- Elsewhere: RCSB PDB 2O6X · PDBe 2O6X · UniProt Q7JNQ9
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