MolNFT v1 · #46369 · protein

Mycobacterium tuberculosis tryptophan synthase beta subunit dimer (apoform)

2O2E · Tryptophan synthase beta chain: “Mycobacterium tuberculosis tryptophan synthase beta subunit dimer (apoform)”. X-ray diffraction, 7 pockets (best druggability 0.83). MolNFT v1 #46369 on GenesisL1: 3D structure, binding sites and…

PDB: 2O2E
Type: protein
Length: 631 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase beta chain
EC: 4.2.1.20
UniProt: P66984
Pockets: 7 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophan synthase beta chain (EC 4.2.1.20)	protein	315	52% helix, 16% strand	P66984
B	Tryptophan synthase beta chain (EC 4.2.1.20)	protein	316	50% helix, 16% strand	P66984

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1007	0.83	0.84	77	empty
2	264	0.61	0.80	32	empty
3	88	0.57	0.87	20	empty
4	94	0.43	0.79	24	empty
5	59	0.30	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 1500 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

2O2E · Mycobacterium tuberculosis tryptophan synthase beta subunit dimer (apoform) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P66984
Elsewhere: RCSB PDB 2O2E · PDBe 2O2E · UniProt P66984

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.