MolNFT v1 · #46345 · protein
Structure of yeast POLY(A) polymerase in a somewhat closed state
2O1P: “Structure of yeast POLY(A) polymerase in a somewhat closed state”. X-ray diffraction, 10 pockets (best druggability 0.67). MolNFT v1 #46345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2O1P
- Type
- protein
- Length
- 1,045 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POLY(A) polymerase
- EC
- 2.7.7.19
- UniProt
- P29468
- Pockets
- 10 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | POLY(A) polymerase (EC 2.7.7.19) | protein | 523 | 43% helix, 16% strand | P29468 |
| B | POLY(A) polymerase (EC 2.7.7.19) | protein | 522 | 43% helix, 17% strand | P29468 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 676 | 0.67 | 0.76 | 69 | empty |
| 2 | 506 | 0.62 | 0.75 | 51 | empty |
| 3 | 138 | 0.38 | 0.73 | 22 | empty |
| 4 | 54 | 0.37 | 0.80 | 12 | empty |
| 5 | 87 | 0.35 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 200 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29468
- Elsewhere: RCSB PDB 2O1P · PDBe 2O1P · UniProt P29468
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