MolNFT v1 · #46157 · protein

Crystal structure of ELS4 TCR at 1.4A

2NW2 · ELS4 TCR alpha chain: “Crystal structure of ELS4 TCR at 1.4A”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1 #46157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2NW2
Type: protein
Length: 439 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ELS4 TCR alpha chain; ELS4 TCR beta chain
UniProt: Q6P4G7, Q32P21
Pockets: 5 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ELS4 TCR alpha chain	protein	196	5% helix, 45% strand	Q6P4G7
B	ELS4 TCR beta chain	protein	243	7% helix, 51% strand	Q32P21

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1025	0.70	0.74	83	empty
2	53	0.31	0.76	17	empty
3	53	0.31	0.76	17	empty
4	54	0.29	0.75	14	empty
5	52	0.26	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 2224 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

2NW2 · Crystal structure of ELS4 TCR at 1.4A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P4G7
Every structure of UniProt Q32P21
Elsewhere: RCSB PDB 2NW2 · PDBe 2NW2 · UniProt Q6P4G7 · UniProt Q32P21

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