MolNFT v1 · #46058 · protein

Crystal structure of slingshot phosphatase 2

2NT2 · Protein phosphatase slingshot homolog 2: “Crystal structure of slingshot phosphatase 2”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.72). MolNFT v1 #46058 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 2NT2
Type: protein
Length: 426 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein phosphatase slingshot homolog 2
EC: 3.1.3.48, 3.1.3.16
UniProt: Q76I76
Ligands: SO4
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Protein phosphatase slingshot homolog 2 (EC 3.1.3.48, 3.1.3.16)	protein	142	46% helix, 18% strand	Q76I76

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1063	0.72	0.76	64	empty
2	71	0.30	0.74	10	empty
3	56	0.26	0.73	13	empty

Interfaces

3 interfaces between chains.

A–B · 386 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 144 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 86 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2NT2 · Crystal Structure of Slingshot phosphatase 2 · the same entry in another collection · chain A against A, TM-score 1.00
Q76I76 · AlphaFold monomer V2.0 prediction for protein phosphatase slingshot homolog 2 (Q76I76) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q76I76
Elsewhere: RCSB PDB 2NT2 · PDBe 2NT2 · UniProt Q76I76

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