MolNFT v1 · #45953 · DNA

Solution structures of a DNA dodecamer duplex with a cisplatin 1,2- D(GG) intrastrand cross-link

2NQ0 · 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3': “Solution structures of a DNA dodecamer duplex with a cisplatin 1,2- D(GG) intrastrand cross-link”. Solution nmr, 1 ligand (CPT). MolNFT v1 #45953 on GenesisL1: 3D structure, binding…

PDB: 2NQ0
Type: DNA
Length: 24 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3'; 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3'
Ligands: CPT

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-D(CPCPTPCPAPGPGPCPCPTPCPC)-3'	dna	12	—	—
B	5'-D(GPGPAPGPGPCPCPTPGPAPGPG)-3'	dna	12	—	—

Ligands and binding sites

CPT · Cisplatin · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 567 Å² buried · 58 hydrogen bonds · nucleic-nucleic

Compared structures

2NQ0 · Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2NQ0 · PDBe 2NQ0

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