MolNFT v1 · #45842 · protein

An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance

2NMR: “An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.61). MolNFT v1 #45842 on GenesisL1: 3D structure, binding…

PDB: 2NMR
Type: protein
Length: 363 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ammonia channel
UniProt: P69681
Ligands: SO4
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ammonia channel	protein	363	74% helix, 2% strand	P69681

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A
ACT · Acetate ion · additive · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.61	0.85	29	empty
2	173	0.46	0.75	23	ACT, GOL

Compared structures

2NMR · An unusual twin-His arrangement in the pore of ammonia channels is essential for… · the same entry in another collection · chain A against A, TM-score 1.00
P69681 · AlphaFold monomer V2.0 prediction for ammonia channel (P69681) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P69681
Elsewhere: RCSB PDB 2NMR · PDBe 2NMR · UniProt P69681

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