MolNFT v1 · #45729 · protein

Solution structure of the T119M variant of transthyretin in its monomeric state

2NBP: “Solution structure of the T119M variant of transthyretin in its monomeric state”. Solution nmr, 2 pockets (best druggability 0.72). MolNFT v1 #45729 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2NBP
Type: protein
Length: 127 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transthyretin
UniProt: P02766
Pockets: 2 · best druggability 0.72

Structure

solution nmr · 1 distinct chain · 6% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transthyretin	protein	127	6% helix, 35% strand	P02766

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.72	0.87	42	empty
2	51	0.33	0.78	14	empty

Compared structures

2NBP · Solution structure of the T119M variant of transthyretin in its monomeric state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02766
Elsewhere: RCSB PDB 2NBP · PDBe 2NBP · UniProt P02766

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