MolNFT v1 · #45605 · protein + RNA

Solution structure of the complex of microrna 20B pre-element with rbfox rrm

2N82 · RNA (5'- R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*…: “Solution structure of the complex of microrna 20B pre-element with rbfox rrm”. Solution nmr, 1 pocket (best druggability 0.67). MolNFT v1 #45605 on GenesisL1: 3D…

PDB: 2N82
Type: protein + RNA
Length: 127 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'- R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP* C)-3')…
UniProt: Q9NWB1
Pockets: 1 · best druggability 0.67

Structure

solution nmr · 2 distinct chains · 21% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA (5'- R(GPGPUPAPGPUPUPUPUPGPGPCPAPUPGPAPCPUPCPUPAPCP* C)-3')	rna	23	—	—
B	RNA binding protein fox-1 homolog 1	protein	104	21% helix, 30% strand	Q9NWB1

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	610	0.67	0.77	45	empty

Interfaces

1 interface between chains.

A–B · 1501 Å² buried · 51 hydrogen bonds · protein-nucleic

Compared structures

2N82 · solution structure of the complex of microRNA 20b pre-element with Rbfox RRM · the same entry in another collection · chain B against B, TM-score 1.00
Q9NWB1 · AlphaFold monomer V2.0 prediction for RNA binding protein fox-1 homolog 1 (Q9NWB1) · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NWB1
Elsewhere: RCSB PDB 2N82 · PDBe 2N82 · UniProt Q9NWB1

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