MolNFT v1 · #45603 · protein
P75NTR DD:RHOGDI
2N80 · Tumor necrosis factor receptor superfamily member 16: “P75NTR DD:RHOGDI”. Solution nmr, 4 pockets (best druggability 0.76). MolNFT v1 #45603 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2N80
- Type
- protein
- Length
- 268 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor necrosis factor receptor superfamily member 16; Rho GDP-dissociation inhibitor 1
- UniProt
- P08138, P52565
- Pockets
- 4 · best druggability 0.76
Structure
solution nmr · 2 distinct chains · 30% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor necrosis factor receptor superfamily member 16 | protein | 94 | 61% helix, 2% strand | P08138 |
| B | Rho GDP-dissociation inhibitor 1 | protein | 174 | 13% helix, 45% strand | P52565 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.76 | 0.96 | 24 | empty |
| 2 | 58 | 0.40 | 0.81 | 17 | empty |
| 3 | 70 | 0.36 | 0.77 | 18 | empty |
| 4 | 53 | 0.31 | 0.77 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 969 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2N80 · p75NTR DD:RhoGDI · the same entry in another collection · chain A against A, TM-score 1.00
- P08138 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member… · a predicted model of the same protein · chain A against A, TM-score 0.84
- P52565 · AlphaFold monomer V2.0 prediction for rho GDP-dissociation inhibitor 1 (P52565) · a predicted model of the same protein · chain B against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08138
- Every structure of UniProt P52565
- Elsewhere: RCSB PDB 2N80 · PDBe 2N80 · UniProt P08138 · UniProt P52565
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.