MolNFT v1 · #45317 · protein

Solution structural studies of GTP:ADENOSYLCOBINAMIDE-phosphate guanylyltransferase (coby) from methanocaldococcus jannaschii

2MZB: “Solution structural studies of GTP:ADENOSYLCOBINAMIDE-phosphate guanylyltransferase (coby) from…”. Solution nmr, 2 pockets (best druggability 0.47). MolNFT v1 #45317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2MZB
Type: protein
Length: 196 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenosylcobinamide-phosphate guanylyltransferase
EC: 2.7.7.62
UniProt: Q58517
Pockets: 2 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 32% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)	protein	196	32% helix, 25% strand	Q58517

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.47	0.78	24	empty
2	50	0.29	0.76	12	empty

Compared structures

2MZB · Solution structural studies of GTP:adenosylcobinamide-phosphate guanylyltransferase… · the same entry in another collection · chain A against A, TM-score 1.00
Q58517 · AlphaFold monomer V2.0 prediction for adenosylcobinamide-phosphate guanylyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q58517
Elsewhere: RCSB PDB 2MZB · PDBe 2MZB · UniProt Q58517

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