MolNFT v1 · #45299 · protein
Myosin subfragment-1, alpha carbon coordinates only for the two light chains
2MYS: “Myosin subfragment-1, alpha carbon coordinates only for the two light chains”. X-ray diffraction, 2 ligands (MG, SO4), 11 pockets (best druggability 0.77). MolNFT v1 #45299 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2MYS
- Type
- protein
- Length
- 1,072 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin
- UniProt
- P13538, P02609, P02605
- Ligands
- MG, SO4
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin | protein | 800 | 47% helix, 14% strand | P13538 |
| B | Myosin | protein | 138 | 0% helix, 0% strand | P02609 |
| C | Myosin | protein | 134 | 0% helix, 0% strand | P02605 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1030 | 0.77 | 0.79 | 93 | empty |
| 2 | 895 | 0.74 | 0.78 | 57 | empty |
| 3 | 495 | 0.62 | 0.75 | 62 | empty |
| 4 | 431 | 0.61 | 0.74 | 58 | empty |
| 5 | 280 | 0.56 | 0.77 | 40 | empty |
Interfaces
3 interfaces between chains.
- A–C · 873 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 820 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 29 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 45 modified (methylation).
Compared structures
- 2MYS · Myosin subfragment-1, alpha carbon coordinates only for the two light chains · the same entry in another collection · chain A against A, TM-score 1.00
- P02605 · AlphaFold monomer V2.0 prediction for myosin light chain 3, skeletal muscle isoform… · a predicted model of the same protein · chain C against A, TM-score 0.91
- P02609 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain 2, skeletal muscle… · a predicted model of the same protein · chain B against A, TM-score 0.84
- P13538 · AlphaFold monomer V2.0 prediction for myosin heavy chain, skeletal muscle, adult (P13538) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13538
- Every structure of UniProt P02609
- Every structure of UniProt P02605
- Elsewhere: RCSB PDB 2MYS · PDBe 2MYS · UniProt P13538 · UniProt P02609 · UniProt P02605
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