MolNFT v1 · #45082 · protein + RNA
Solution NMR structure pf TRNAPRO:MLV-nucleocapsid (1:2) complex
2MS0 · Nucleocapsid protein P10: “Solution NMR structure pf TRNAPRO:MLV-nucleocapsid (1:2) complex”. Solution nmr, 1 ligand (ZN), 4 pockets (best druggability 0.65). MolNFT v1 #45082 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2MS0
- Type
- protein + RNA
- Length
- 182 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleocapsid protein P10; Trnapro
- UniProt
- P03355
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.65
Structure
solution nmr · 3 distinct chains · 9% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleocapsid protein P10 | protein | 55 | 13% helix, 4% strand | P03355 |
| B | Trnapro | rna | 71 | — | — |
| C | Nucleocapsid protein P10 | protein | 56 | 5% helix, 4% strand | P03355 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 337 | 0.65 | 0.81 | 28 | empty |
| 2 | 445 | 0.56 | 0.74 | 28 | empty |
| 3 | 153 | 0.43 | 0.76 | 19 | empty |
| 4 | 100 | 0.31 | 0.72 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1113 Ų buried · 37 hydrogen bonds · protein-nucleic
- B–C · 821 Ų buried · 19 hydrogen bonds · protein-nucleic
- A–C · 375 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2MS0 · Solution NMR structure pf tRNApro:MLV-Nucleocapsid (1:2) Complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Elsewhere: RCSB PDB 2MS0 · PDBe 2MS0 · UniProt P03355
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