MolNFT v1 · #45051 · protein + RNA

Structural investigation of hnrnp L bound to RNA

2MQQ · Heterogenous nuclear ribonucleoprotein L: “Structural investigation of hnrnp L bound to RNA”. Solution nmr, 1 pocket (best druggability 0.42). MolNFT v1 #45051 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2MQQ
Type: protein + RNA
Length: 225 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heterogenous nuclear ribonucleoprotein L; RNA (5'-R(*AP*CP*AP*CP*A)-3')
UniProt: Q5U1Y5
Pockets: 1 · best druggability 0.42

Structure

solution nmr · 2 distinct chains · 21% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heterogenous nuclear ribonucleoprotein L	protein	215	21% helix, 26% strand	Q5U1Y5
B, C	RNA (5'-R(APCPAPCP*A)-3')	rna	5	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.42	0.79	19	empty

Interfaces

2 interfaces between chains.

A–C · 1126 Å² buried · 37 hydrogen bonds · protein-nucleic
A–B · 753 Å² buried · 19 hydrogen bonds · protein-nucleic

Compared structures

2MQQ · Structural Investigation of hnRNP L bound to RNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5U1Y5
Elsewhere: RCSB PDB 2MQQ · PDBe 2MQQ · UniProt Q5U1Y5

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