MolNFT v1 · #44828 · protein + RNA

Solution structure of the gld-1 RNA-binding domain in complex with RNA

2MJH · Female germline-specific tumor suppressor gld-1: “Solution structure of the gld-1 RNA-binding domain in complex with RNA”. Solution nmr, 3 pockets (best druggability 0.35). MolNFT v1 #44828 on GenesisL1: 3D structure, binding sites…

PDB: 2MJH
Type: protein + RNA
Length: 152 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Female germline-specific tumor suppressor gld-1; 5'-cuacucauau-3'
UniProt: Q17339
Pockets: 3 · best druggability 0.35

Structure

solution nmr · 2 distinct chains · 35% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Female germline-specific tumor suppressor gld-1	protein	142	35% helix, 16% strand	Q17339
B	5'-cuacucauau-3'	rna	10	—	—

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.35	0.77	15	empty
2	59	0.29	0.75	17	empty
3	52	0.25	0.73	9	empty

Interfaces

1 interface between chains.

A–B · 1442 Å² buried · 43 hydrogen bonds · protein-nucleic

Compared structures

2MJH · Solution structure of the GLD-1 RNA-binding domain in complex with RNA · the same entry in another collection · chain A against A, TM-score 1.00
Q17339 · AlphaFold monomer V2.0 prediction for female germline-specific tumor suppressor gld-1… · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q17339
Elsewhere: RCSB PDB 2MJH · PDBe 2MJH · UniProt Q17339

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