MolNFT v1 · #44806 · DNA

NMR studies of N2-guanine adducts derived from the tumorigen DIBENZO[A,L]PYRENE in DNA: impact of adduct stereochemistry, size, and local DNA structure on solution conformations

2MIV · DNA_(5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'): “NMR studies of N2-guanine adducts derived from the tumorigen DIBENZO[A,L]PYRENE in DNA: impact of adduct…”. Solution nmr, 1 ligand (2QL). MolNFT v1 #44806 on GenesisL1: 3D structure…

PDB: 2MIV
Type: DNA
Length: 21 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA_(5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3')…
Ligands: 2QL

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA_(5'-D(CPCPAPTPCPGPCPTPAPCP*C)-3')	dna	11	—	—
B	DNA_(5'-D(GPGPTPAPGPGPAPTPGPG)-3')	dna	10	—	—

Ligands and binding sites

2QL · (11R,12R,13R)-11,12,13,14-tetrahydronaphtho[1,2,3,4-pqr]tetraphene-11,12,13-triol · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 461 Å² buried · 44 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

2MIV · NMR studies of N2-guanine adducts derived from the tumorigen dibenzo[a,l]pyrene in DNA… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2MIV · PDBe 2MIV

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.