MolNFT v1 · #44770 · protein
Solution structure of the major factor VIII binding region on von willebrand factor
2MHP: “Solution structure of the major factor VIII binding region on von willebrand factor”. Solution nmr, 2 pockets (best druggability 0.34). MolNFT v1 #44770 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2MHP
- Type
- protein
- Length
- 103 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Von willebrand factor
- UniProt
- P04275
- Pockets
- 2 · best druggability 0.34
Structure
solution nmr · 1 distinct chain · 3% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Von willebrand factor | protein | 103 | 3% helix, 31% strand | P04275 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.34 | 0.76 | 16 | empty |
| 2 | 77 | 0.33 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2MHP · Solution structure of the major factor VIII binding region on von Willebrand factor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04275
- Elsewhere: RCSB PDB 2MHP · PDBe 2MHP · UniProt P04275
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