MolNFT v1 · #44714 · protein
Computational design and experimental verification of a symmetric protein homodimer
2MG4 · Computational designed homodimer: “Computational design and experimental verification of a symmetric protein homodimer”. Solution nmr, 3 pockets (best druggability 0.51). MolNFT v1 #44714 on GenesisL1: 3D structure, binding sites…
- PDB
- 2MG4
- Type
- protein
- Length
- 132 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Computational designed homodimer
- Pockets
- 3 · best druggability 0.51
Structure
solution nmr · 1 distinct chain · 45% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Computational designed homodimer | protein | 66 | 45% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 122 | 0.51 | 0.81 | 24 | empty |
| 2 | 129 | 0.49 | 0.79 | 21 | empty |
| 3 | 53 | 0.27 | 0.74 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 966 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 2MG4 · Computational design and experimental verification of a symmetric protein homodimer · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2MG4 · PDBe 2MG4
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