MolNFT v1 · #44674 · protein
Structure of the tetrameric building block of the salmonella typhimurium prgi type three secretion system needle
2MEX · Protein prgi: “Structure of the tetrameric building block of the salmonella typhimurium prgi type three secretion system…”. Solid-state nmr, 8 pockets (best druggability 0.69). MolNFT v1 #44674 on GenesisL1: 3D structure, binding…
- PDB
- 2MEX
- Type
- protein
- Length
- 320 residues
- Chains
- 4
- Method
- solid-state nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein prgi
- UniProt
- P41784
- Pockets
- 8 · best druggability 0.69
Structure
solid-state nmr · 1 distinct chain · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Protein prgi | protein | 80 | 79% helix, 0% strand | P41784 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.69 | 0.88 | 21 | empty |
| 2 | 94 | 0.62 | 0.88 | 21 | empty |
| 3 | 172 | 0.49 | 0.77 | 25 | empty |
| 4 | 159 | 0.49 | 0.77 | 19 | empty |
| 5 | 51 | 0.46 | 0.85 | 20 | empty |
Interfaces
5 interfaces between chains.
- B–D · 734 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 680 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 667 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 643 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 527 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2MEX · Structure of the tetrameric building block of the Salmonella Typhimurium PrgI Type three… · the same entry in another collection · chain A against A, TM-score 1.00
- P41784 · AlphaFold monomer V2.0 prediction for protein prgi (P41784) · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41784
- Elsewhere: RCSB PDB 2MEX · PDBe 2MEX · UniProt P41784
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