MolNFT v1 · #44620 · protein

Structure of uninhibited ETV6 ets domain

2MD5 · Transcription factor ETV6: “Structure of uninhibited ETV6 ets domain”. Solution nmr, 2 pockets (best druggability 0.69). MolNFT v1 #44620 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2MD5
Type: protein
Length: 102 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription factor ETV6
UniProt: P97360
Pockets: 2 · best druggability 0.69

Structure

solution nmr · 1 distinct chain · 37% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription factor ETV6	protein	102	37% helix, 16% strand	P97360

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.69	0.96	14	empty
2	54	0.42	0.82	10	empty

Compared structures

2MD5 · Structure of uninhibited ETV6 ETS domain · the same entry in another collection · chain A against A, TM-score 1.00
P97360 · AlphaFold monomer V2.0 prediction for transcription factor ETV6 (P97360) · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P97360
Elsewhere: RCSB PDB 2MD5 · PDBe 2MD5 · UniProt P97360

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