MolNFT v1 · #44418 · protein

Structure of the P7 channel of hepatitis C virus, genotype 5A

2M6X: “Structure of the P7 channel of hepatitis C virus, genotype 5A”. Solution nmr, 9 pockets (best druggability 0.73). MolNFT v1 #44418 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2M6X
Type: protein
Length: 378 residues
Chains: 6
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P7
UniProt: O39928
Pockets: 9 · best druggability 0.73

Structure

solution nmr · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	P7	protein	63	73% helix, 0% strand	O39928

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	627	0.73	0.79	75	empty
2	248	0.65	0.82	39	empty
3	306	0.63	0.80	42	empty
4	287	0.62	0.79	37	empty
5	310	0.61	0.78	22	empty

Interfaces

15 interfaces between chains.

A–B · 889 Å² buried · 2 hydrogen bonds · protein-protein
A–F · 870 Å² buried · 2 hydrogen bonds · protein-protein
E–F · 858 Å² buried · 1 hydrogen bond · protein-protein
C–D · 835 Å² buried · 5 hydrogen bonds · protein-protein
D–E · 811 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2M6X · Structure of the p7 channel of Hepatitis C virus, genotype 5a · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O39928
Elsewhere: RCSB PDB 2M6X · PDBe 2M6X · UniProt O39928

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