MolNFT v1 · #44325 · protein
Solution structure of the axh domain of ataxin-1 in complex with ligand peptide from capicua
2M41 · Protein capicua homolog: “Solution structure of the axh domain of ataxin-1 in complex with ligand peptide from capicua”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #44325 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2M41
- Type
- protein
- Length
- 138 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein capicua homolog; Ataxin-1
- UniProt
- Q96RK0, P54253
- Pockets
- 1 · best druggability 0.29
Structure
solution nmr · 2 distinct chains · 15% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein capicua homolog | protein | 15 | 0% helix, 13% strand | Q96RK0 |
| B | Ataxin-1 | protein | 123 | 17% helix, 37% strand | P54253 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.29 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1066 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2M41 · Solution Structure of the AXH domain of Ataxin-1 in complex with ligand peptide from… · the same entry in another collection · chain A against A, TM-score 1.00
- P54253 · AlphaFold monomer V2.0 prediction for ataxin-1 (P54253) · a predicted model of the same protein · chain B against A, TM-score 0.79
- Q96RK0 · AlphaFold monomer V2.0 prediction for protein capicua homolog (Q96RK0) · a predicted model of the same protein · chain A against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96RK0
- Every structure of UniProt P54253
- Elsewhere: RCSB PDB 2M41 · PDBe 2M41 · UniProt Q96RK0 · UniProt P54253
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