MolNFT v1 · #44235 · protein

Haddock structure of gtyybt pas homodimer

2M1C · Dhh subfamily 1 protein: “Haddock structure of gtyybt pas homodimer”. Solution nmr, 3 pockets (best druggability 0.85). MolNFT v1 #44235 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2M1C
Type: protein
Length: 226 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dhh subfamily 1 protein
UniProt: A4ITV2
Pockets: 3 · best druggability 0.85

Structure

solution nmr · 1 distinct chain · 17% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dhh subfamily 1 protein	protein	113	17% helix, 22% strand	A4ITV2

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	448	0.85	0.91	60	empty
2	56	0.61	0.91	15	empty
3	57	0.59	0.90	15	empty

Interfaces

1 interface between chains.

A–B · 1319 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

2M1C · HADDOCK structure of GtYybT PAS Homodimer · the same entry in another collection · chain A against A, TM-score 1.00
A4ITV2 · AlphaFold monomer V2.0 prediction for cyclic-di-AMP phosphodiesterase gdpp (A4ITV2) · a predicted model of the same protein · chain A against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A4ITV2
Elsewhere: RCSB PDB 2M1C · PDBe 2M1C · UniProt A4ITV2

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