MolNFT v1 · #44140 · protein
The solution structure of the dm DCP1 EVH1 domain in complex with the XRN1 dbm peptide
2LYD · Decapping protein 1: “The solution structure of the dm DCP1 EVH1 domain in complex with the XRN1 dbm peptide”. Solution nmr, 1 pocket (best druggability 0.76). MolNFT v1 #44140 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2LYD
- Type
- protein
- Length
- 172 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Decapping protein 1; Pacman protein
- UniProt
- Q9W1H5, Q9XZU2
- Pockets
- 1 · best druggability 0.76
Structure
solution nmr · 2 distinct chains · 26% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Decapping protein 1 | protein | 134 | 25% helix, 46% strand | Q9W1H5 |
| B | Pacman protein | protein | 38 | 29% helix, 0% strand | Q9XZU2 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 136 | 0.76 | 0.94 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 779 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2LYD · The solution structure of the Dm DCP1 EVH1 domain in complex with the XRN1 DBM peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9W1H5
- Every structure of UniProt Q9XZU2
- Elsewhere: RCSB PDB 2LYD · PDBe 2LYD · UniProt Q9W1H5 · UniProt Q9XZU2
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