MolNFT v1 · #44024 · protein
Solution-state NMR structure of prion protein mutant V210I at neutral pH
2LV1 · Major prion protein: “Solution-state NMR structure of prion protein mutant V210I at neutral pH”. Solution nmr, 2 pockets (best druggability 0.37). MolNFT v1 #44024 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2LV1
- Type
- protein
- Length
- 147 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major prion protein
- UniProt
- P04156
- Pockets
- 2 · best druggability 0.37
Structure
solution nmr · 1 distinct chain · 41% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major prion protein | protein | 147 | 41% helix, 3% strand | P04156 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.37 | 0.81 | 15 | empty |
| 2 | 71 | 0.33 | 0.75 | 12 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2LV1 · Solution-state NMR structure of prion protein mutant V210I at neutral pH · the same entry in another collection · chain A against A, TM-score 1.00
- P04156 · AlphaFold monomer V2.0 prediction for major prion protein (P04156) · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04156
- Elsewhere: RCSB PDB 2LV1 · PDBe 2LV1 · UniProt P04156
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