MolNFT v1 · #43689 · protein

Structural basis of phosphoinositide binding to kindlin-2 pleckstrin homology domain in regulating integrin activation

2LKO · Fermitin family homolog 2: “Structural basis of phosphoinositide binding to kindlin-2 pleckstrin homology domain in regulating integrin…”. Solution nmr, 1 ligand (4IP), 1 pocket (best druggability 0.74). MolNFT v1 #43689 on…

PDB: 2LKO
Type: protein
Length: 138 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fermitin family homolog 2
UniProt: Q96AC1
Ligands: 4IP
Pockets: 1 · best druggability 0.74

Structure

solution nmr · 1 distinct chain · 23% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fermitin family homolog 2	protein	138	23% helix, 28% strand	Q96AC1

Ligands and binding sites

4IP · Inositol-(1,3,4,5)-tetrakisphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	426	0.74	0.83	40	4IP

Compared structures

2LKO · Structural Basis of Phosphoinositide Binding to Kindlin-2 Pleckstrin Homology Domain in… · the same entry in another collection · chain A against A, TM-score 1.00
Q96AC1 · AlphaFold monomer V2.0 prediction for fermitin family homolog 2 (Q96AC1) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96AC1
Elsewhere: RCSB PDB 2LKO · PDBe 2LKO · UniProt Q96AC1

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