MolNFT v1 · #43625 · protein

NMR solution structure of yeast iso-1-cytochrome C mutant P71H in oxidized states

2LIR · Cytochrome C iso-1: “NMR solution structure of yeast iso-1-cytochrome C mutant P71H in oxidized states”. Solution nmr, 1 ligand (HEC), 1 pocket (best druggability 0.75). MolNFT v1 #43625 on GenesisL1: 3D structure, binding sites and…

PDB: 2LIR
Type: protein
Length: 108 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome C iso-1
UniProt: P00044
Ligands: HEC
Pockets: 1 · best druggability 0.75

Structure

solution nmr · 1 distinct chain · 42% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome C iso-1	protein	108	42% helix, 2% strand	P00044

Ligands and binding sites

HEC · Heme C · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	347	0.75	0.85	43	HEC

Modifications

Observed in the structure: 2 cofactor (heme c attachment).

Compared structures

2LIR · NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in oxidized states · the same entry in another collection · chain A against A, TM-score 1.00
P00044 · AlphaFold monomer V2.0 prediction for cytochrome C isoform 1 (P00044) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00044
Elsewhere: RCSB PDB 2LIR · PDBe 2LIR · UniProt P00044

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