MolNFT v1 · #43581 · protein

Refinement of a molecular model for lamprey hemoglobin from petromyzon marinus

2LHB · Hemoglobin V (cyano met): “Refinement of a molecular model for lamprey hemoglobin from petromyzon marinus”. X-ray diffraction, 2 ligands (HEM, CYN), 2 pockets (best druggability 0.73). MolNFT v1 #43581 on GenesisL1: 3D structure…

PDB: 2LHB
Type: protein
Length: 149 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemoglobin V (cyano met)
UniProt: P02208
Ligands: HEM, CYN
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hemoglobin V (cyano met)	protein	149	76% helix, 0% strand	P02208

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
CYN · Cyanide ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	276	0.73	0.86	30	CYN, HEM
2	58	0.31	0.75	14	empty

Compared structures

2LHB · Refinement of a molecular model for lamprey hemoglobin from petromyzon marinus · the same entry in another collection · chain A against A, TM-score 1.00
P02208 · AlphaFold monomer V2.0 prediction for globin-5 (P02208) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02208
Elsewhere: RCSB PDB 2LHB · PDBe 2LHB · UniProt P02208

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