MolNFT v1 · #43479 · DNA
Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface
2LE6 · DNA (5'-D(*GP*IP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)…: “Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface”. Solution nmr, 3 pockets (best druggability 0.38). MolNFT v1 #43479 on…
- PDB
- 2LE6
- Type
- DNA
- Length
- 32 nucleotides
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*GP*IP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)- 3')
- Pockets
- 3 · best druggability 0.38
Structure
solution nmr · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA (5'-D(*GP*IP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)- 3') | dna | 16 | — | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.38 | 0.76 | 12 | empty |
| 2 | 84 | 0.35 | 0.76 | 12 | empty |
| 3 | 67 | 0.31 | 0.76 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 439 Ų buried · 9 hydrogen bonds · nucleic-nucleic
Compared structures
- 2LE6 · Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5'… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2LE6 · PDBe 2LE6
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