MolNFT v1 · #43474 · protein

Parp brct domain

2LE0 · Poly [ADP-ribose] polymerase 1: “Parp brct domain”. Solution nmr, 1 pocket (best druggability 0.31). MolNFT v1 #43474 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2LE0
Type: protein
Length: 106 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Poly [ADP-ribose] polymerase 1
EC: 2.4.2.30
UniProt: P27008
Pockets: 1 · best druggability 0.31

Structure

solution nmr · 1 distinct chain · 38% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30)	protein	106	38% helix, 11% strand	P27008

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.31	0.75	18	empty

Compared structures

2LE0 · PARP BRCT Domain · the same entry in another collection · chain A against A, TM-score 1.00
P27008 · AlphaFold monomer V2.0 prediction for poly [ADP-ribose] polymerase 1 (P27008) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27008
Elsewhere: RCSB PDB 2LE0 · PDBe 2LE0 · UniProt P27008

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