MolNFT v1 · #43471 · protein
Characterization of the antigenic sites on the refined 3- ångströms resolution structure of mouse testicular lactate dehydrogenase C4
2LDX · Apo-lactate dehydrogenase: “Characterization of the antigenic sites on the refined 3- ångströms resolution structure of mouse testicular…”. X-ray diffraction, 15 pockets (best druggability 0.87). MolNFT v1 #43471 on GenesisL1: 3D…
- PDB
- 2LDX
- Type
- protein
- Length
- 1,324 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apo-lactate dehydrogenase
- EC
- 1.1.1.27
- UniProt
- P00342
- Pockets
- 15 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Apo-lactate dehydrogenase (EC 1.1.1.27) | protein | 331 | 38% helix, 19% strand | P00342 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1151 | 0.87 | 0.88 | 131 | empty |
| 2 | 658 | 0.84 | 0.88 | 80 | empty |
| 3 | 156 | 0.80 | 0.96 | 29 | empty |
| 4 | 150 | 0.79 | 0.96 | 30 | empty |
| 5 | 146 | 0.79 | 0.96 | 30 | empty |
Interfaces
6 interfaces between chains.
- B–D · 2441 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 2426 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 1454 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 1454 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 1222 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 2LDX · Characterization of the antigenic sites on the refined 3-ångströms resolution structure… · the same entry in another collection · chain A against A, TM-score 1.00
- P00342 · AlphaFold monomer V2.0 prediction for L-lactate dehydrogenase C chain (P00342) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00342
- Elsewhere: RCSB PDB 2LDX · PDBe 2LDX · UniProt P00342
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