MolNFT v1 · #43429 · protein

Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment replacement

2LCK: “Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment replacement”. Solution nmr, 7 pockets (best druggability 0.61). MolNFT v1 #43429 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2LCK
Type: protein
Length: 297 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial uncoupling protein 2
UniProt: P70406
Pockets: 7 · best druggability 0.61

Structure

solution nmr · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitochondrial uncoupling protein 2	protein	297	71% helix, 0% strand	P70406

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	421	0.61	0.76	50	empty
2	272	0.57	0.77	32	empty
3	190	0.51	0.77	27	empty
4	236	0.49	0.74	22	empty
5	73	0.43	0.81	14	empty

Compared structures

2LCK · Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment… · the same entry in another collection · chain A against A, TM-score 1.00
P70406 · AlphaFold monomer V2.0 prediction for mitochondrial uncoupling protein 2 (P70406) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P70406
Elsewhere: RCSB PDB 2LCK · PDBe 2LCK · UniProt P70406

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